Formulation and Evaluation of Orally Disintegrating Films of Levocetirizine Dihydrochloride

For the past one decade, there has been an enhanced demand for more patient-friendly and compliant dosage forms. As a result, the demand for developing new technologies has been increasing annually. Orally disintegrating films (ODF) have carved a niche amongst the oral drug delivery systems due to their high patient compliance[1-3]. United States Food and Drug Administration (USFDA) defined the fast dissolving oral thin films as “a thin, flexible, non-friable polymeric film strip containing one or more dispersed/dissolved active pharmaceutical ingredients, which is intended to be placed on the tongue for rapid in vitro disintegration or dissolution in the saliva prior to swallowing for delivery into the gastrointestinal tract”[4].